recombinant tnf alpha
It is mainly produced by monocytes and macrophages as a response to infection injury or tumor burden. Ad Cell culture proteins providing consistency with market leading QC utilising HPLC and MS.
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Tumor necrosis factor alpha TNF-α is a cytokine that plays a central role in inflammation immune system development apoptosis and lipid metabolism.
. Ad High bioactivity verified by cell based assay FACS ELISA SPR etc. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance By similarity. Ad Cell culture proteins providing consistency with market leading QC utilising HPLC and MS.
Human TNF-alpha Recombinant Protein View all Human TNF-alpha Proteins Datasheet Tech Support Product Details Product Specific Information Reconstitution. ISO9001 manufactured ensuring highest purity ultra-low endotoxin is consistently achieved. Find recombinant tnf-alpha and related products for scientific research at MilliporeSigma.
Gene Ontology GO annotations related to this gene include identical protein binding and cytokine activity. Products Building Blocks Explorer Technical Documents Site Content Papers Genes. The 157 amino acid protein has a predicted molecular weight of 175kDa.
It is recommended that the protein be aliquoted and used as soon as possible. Recombinant Human tumor necrosis factor alpha is an E. High-quality TNF-alpha proteins from ACROBiosystems.
Using the advantages of SUMO-fusion technology we were able to produce protein with an authentic N-terminus in high yield. Ad Human TNF alpha proteins - Expressed in HEK293 cells - Cited in 16 publications. Ad High bioactivity verified by cell based assay FACS ELISA SPR etc.
A The biological activity of Mouse Recombinant TNF-alpha was tested by its ability to induce cytolysis of L929 cells growing in the presence of actinomycin D. GeneCards Summary for TNF Gene. Among its related pathways are EBV LMP1 signaling and Bacterial infections in CF airways.
PTHR11471SF23 PTHR11471SF23 1 hit. TNF Tumor Necrosis Factor is a Protein Coding gene. It is a pleiotropic molecule that plays a central role in inflammation immune system development apoptosis and lipid metabolism 1 2.
Mouse TNF-alpha consisits of a 35 amino acid aa cytoplasmic domain a 21 aa transmembrane segment and a 179 aa extracellular domain ECD 3. We have therefore established a protocol for the rapid high-level synthesis of recombinant human TNF-alpha in Escherichia coli shake-flask cultures and the subsequent purification of the mature protein. TNF-α plays roles in antitumor activity immune modulation inflammation anorexia cachexia septic shock.
Dissolve the protein in sterile double-distilled water to a concentration of 02 mgmL or lower. Product Details Target Species Human Product Form Purified recombinant cytokine - lyophilized. The N-terminal amino acid is Val.
ISO9001 manufactured ensuring highest purity ultra-low endotoxin is consistently achieved. There are 11 TNF-alpha protein produced in house with high quality which are covering various species. High-quality TNF-alpha proteins from ACROBiosystems.
Recombinant Human Tumor Necrosis Factor alpha with HSA Tumor necrosis factor-alpha TNF-α is a pleiotropic inflammatory cytokine produced by several types of cells predominantly activated macrophages. The DTT-reduced protein and non-reduced protein migrate at approximately 16kDa by SDS-PAGE. Over 95 purity of the recombinant anti-TNF-α fusion proteins was obtained by just one purification step in our developed prokaryotic expression system while the results of surface plasmon resonance SPR established the high-efficiency potent binding ability of.
Plays a role in angiogenesis by inducing VEGF production. Diseases associated with TNF include Malaria and Asthma. Cell viability was measured after 19 hours of culture using a fluorometric assay method.
Ad Expert Technical Support. Applications Products Services Support. Molecular Mass The 157 amino acid recombinant protein has a predicted molecular mass of 17352 Da.
Ad Expert Technical Support. Among these TNF-alpha proteins there are 4 Human TNF-alpha protein 2 Mouse TNF-alpha protein 1 Ferret TNF-alpha protein 1 Canine TNF-alpha protein 1 Rat TNF-alpha protein 1 Cynomolgus Rhesus TNF-alpha protein 1 Cynomolgus TNF-alpha protein. TNF-α plays an important role in the immune response to microbial invasions and in the necrosis of specific tumors.
Tumore necrosis factor-α TNF-α also known as cachectin is expressed as a 26 kDa membrane bound protein and is then cleaved by TNF-α converting enzyme TACE to release the soluble 17 kDa monomer which forms homotrimers in circulation. Within the ECD mouse TNF-alpha shares 94 aa sequence. Recombinant Human TNF alpha accession number Q9GZX6 Val77-Leu233 is expressed in Ecoli.
Human TNF-α amino acids Val77-Leu233 Accession NM_000594 was expressed in E. Ad Human TNF alpha proteins - Expressed in HEK293 cells - Cited in 16 publications. CRT192C Recombinant Mouse TNF-alpha Sign in or register to save this reagent to your favourites Protein info Additional info Supplier Cell Sciences Expression System Escherichia coli Purified Yes Bioactive Yes Nature Recombinant Classification Cytokine Protein Name Tumor necrosis factor UniProt ID P06804 - TNFA_MOUSE Species Mus musculus Mouse.
The protein migrates at approximately 16kDa on. Coli -derived recombinant protein corresponding to the C-terminal domain of human tumour necrosis factor alpha TNFa a pro-inflammatory cytokine with cytotoxic effects on various tumour cells.
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